107430-91-1Relevant academic research and scientific papers
S1P RECEPTORS MODULATORS AND THEIR USE THEREOF
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Page/Page column 81-82, (2010/04/30)
The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.
Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties
Simoni, Daniele,Rondanin, Riccardo,Baruchello, Riccardo,Rizzi, Michele,Grisolia, Giuseppina,Eleopra, Marco,Grimaudo, Stefania,Di Cristina, Antonietta,Pipitone, Maria Rosaria,Bongiorno, Maria Rita,Aricò, Mario,Invidiata, Francesco Paolo,Tolomeo, Manlio
experimental part, p. 4796 - 4803 (2009/07/25)
A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.
Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same
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, (2008/06/13)
A polycyclic aromatic compound having the formula STR1 and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula, X represents --CH=CH--, O or S, R1 represents hydrogen, branched alkyl having 3-15 carbo
