107444-51-9 Usage
Uses
Different sources of media describe the Uses of 107444-51-9 differently. You can refer to the following data:
1. Diabetes?II?-?not?yet?an?approved?application
2. Glucagon-Like Peptide-1 is used as a Effector in the hormonal control of insulin secretion. The peptide fragment is secreted from the lower small intestine. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells.
3. Glucagon-Like Peptide (GLP) I Amide Fragment 7-36 human has been used as a GLP-1 receptor agonist: in lysate transfer cyclic adenosine monophosphate (cAMP) assay to test its effect on adenylyl cyclase activityto pre-treat the human umbilical vein endothelial cells (HUVECs) to monitor its effect on hyperpermeability in endothelial cell (EC) monolayers and changes with the actin cytoskeletonto test its inhibitory effect on vascular endothelial growth factor-A (VEGFA) based vasodilation in rat mesenteric arteries
General Description
Glucagon-like peptide 1 (GLP-1) peptide is obtained from proglucagon and is metabolically inactive. However, it is processed to two smaller amide forms, namely GLP-1 (7-37) amide and GLP-1 (7-36) amide. It is a natural gastrointestinal peptide.
Biochem/physiol Actions
GLP-1 (glucagon-like peptide 1) (7-36) amide is a potent insulinotropic peptide, which initiates the glucose-induced insulin release after meals or oral glucose intake. It has an anti-diabetogenic effect and thus, might have use in the treatment of non-insulin dependent diabetes mellitus.
Check Digit Verification of cas no
The CAS Registry Mumber 107444-51-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,4,4 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 107444-51:
(8*1)+(7*0)+(6*7)+(5*4)+(4*4)+(3*4)+(2*5)+(1*1)=109
109 % 10 = 9
So 107444-51-9 is a valid CAS Registry Number.