107452-89-1

Basic information

• Product Name: Ziconotide acetate
• Synonyms: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETATE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDE BRIDGE: 1-16, 8-20, AND 15-25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDE BRIDGE: 1-16,8-20, AND 15-25)
• CAS NO: 107452-89-1
• Molecular Formula: C102H172N36O32S7
• Molecular Weight: 2639.13
• Product Categories: Peptide
• Mol File: 107452-89-1.mol
• Article Data: 0

Chemical Properties

• Appearance: white powder
• Density: 1.60±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• CAS DataBase Reference: Ziconotide acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ziconotide acetate(107452-89-1)
• EPA Substance Registry System: Ziconotide acetate(107452-89-1)

Safety Data

• RIDADR: 3172
• WGK Germany: 3
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 107452-89-1(Hazardous Substances Data)

Usage

Description

Ziconotide acetate, also known as ω-Conotoxin MVIIA, is a synthetic peptide derived from the venom of the Conus magus (cone snail). It is a selective antagonist of N-type voltage-sensitive calcium channels (VSCCs) and has analgesic and neuroprotective effects. Ziconotide acetate is a promising pharmaceutical candidate for the treatment of neuropathic pain.
Source:
Ziconotide acetate is derived from the venom of the Conus magus (cone snail).
Production Methods:
The production method of Ziconotide acetate is not provided in the materials.

Uses

Used in Pharmaceutical Industry:
Ziconotide acetate is used as a ligand for binding studies of voltage-sensitive calcium channels. It is a selective antagonist of N-type VSCCs, which helps in blocking neurotransmitter release by preventing depolarization-induced calcium influx.
Used in Pain Management:
Ziconotide acetate is used as an analgesic for the treatment of neuropathic pain. It has been found to be effective in managing severe chronic pain that is not responsive to other treatments.
Used in Neuroprotection:
Ziconotide acetate is used for its neuroprotective effects, which can help in protecting the nervous system from damage and degeneration.
Brand Name:
Prialt (Elan) is the brand name under which Ziconotide acetate is marketed.

Biochem/physiol Actions

Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses.

InChI:InChI=1/C102H172N36O32S7/c1-50(2)34-63-91(161)127-62(26-33-171-5)90(160)129-64(35-53-22-24-54(143)25-23-53)92(162)130-65(36-78(148)149)93(163)135-72-48-175-173-45-69(80(108)150)133-86(156)58(18-8-12-29-105)121-76(146)39-117-85(155)66(41-139)131-88(158)61(21-15-32-114-102(111)112)126-96(166)70-46-176-177-47-71(97(167)132-68(43-141)95(165)125-60(87(157)128-63)20-14-31-113-101(109)110)134-89(159)59(19-9-13-30-106)123-81(151)51(3)119-74(144)37-115-83(153)56(16-6-10-27-103)120-75(145)38-116-84(154)57(17-7-11-28-104)124-82(152)55(107)44-172-174-49-73(137-98(72)168)99(169)138-79(52(4)142)100(170)118-40-77(147)122-67(42-140)94(164)136-70/h22-25,50-52,55-73,79,139-143H,6-21,26-49,103-107H2,1-5H3,(H2,108,150)(H,115,153)(H,116,154)(H,117,155)(H,118,170)(H,119,144)(H,120,145)(H,121,146)(H,122,147)(H,123,151)(H,124,152)(H,125,165)(H,126,166)(H,127,161)(H,128,157)(H,129,160)(H,130,162)(H,131,158)(H,132,167)(H,133,156)(H,134,159)(H,135,163)(H,136,164)(H,137,168)(H,138,169)(H,148,149)(H4,109,110,113)(H4,111,112,114)