107479-83-4Relevant academic research and scientific papers
Synthesis of 3,4-benzo-7-hydroxy-2,9-diazabicyclo[3.3.1]non-7-enes by cyclization of 1,3-bis(silyl enol ethers) with quinazolines
Karapetyan, Vahuni,Mkrtchyan, Satenik,Schmidt, Andreas,Guetlein, Joerg-Peter,Villinger, Alexander,Reinke, Helmut,Jiao, Haijun,Fischer, Christine,Langer, Peter
, p. 2961 - 2968 (2008)
A variety of functionalized 3,4-benzo-7-hydroxy-2,9-diazabicyclo[3.3.1]non- 7-enes were prepared by one-pot cyclizations of 1,3-bis(silyl enol ethers) with quinazolines. The mechanism of the cyclization was studied by B3LYP/6-31G(d) density functional theory computations. The products could be functionalized by Suzuki cross-coupling reactions. The reaction of 1,3-bis(silyl enol ethers) with phthalazine afforded open-chain rather than cyclization products. The Royal Society of Chemistry.
