107484-69-5

Basic information

• Product Name: 5-chloro-8-iodo-1,6-naphthyridine
• Synonyms: 5-chloro-8-iodo-1,6-naphthyridine
• CAS NO: 107484-69-5
• Molecular Formula: C8H4ClIN2
• Molecular Weight: 290.48823
• Mol File: 107484-69-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 383.2±37.0 °C(Predicted)
• Appearance: /
• Density: 2.017±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.02±0.30(Predicted)
• CAS DataBase Reference: 5-chloro-8-iodo-1,6-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-8-iodo-1,6-naphthyridine(107484-69-5)
• EPA Substance Registry System: 5-chloro-8-iodo-1,6-naphthyridine(107484-69-5)

Safety Data

• Hazardous Substances Data: 107484-69-5(Hazardous Substances Data)

Upstream product

• 107484-68-4 8-iodo-1,6-naphthyridin-5(6H)-one 
• 23616-31-1 1,6-naphthyridine-5(6H)-one 

Relevant articles and documents

Condensed Heteroaromatic Ring Systems. V. Formal Synthesis of Matrine and Related Compounds Using Palladium-Catalyzed Carbon-Carbon Bond Formations as Key Reactions

The iodonation and subsequent dehydroxychlorination of 1,6-naphthyridin-5(6H)-one gave 5-chloro-8-iodo-1,6-naphthyridine, wich was converted to the 5-methoxy derivative.Starting from this compound, didehydromatrine was synthesized by using palladium-catalyzed cross-coupling reactions with ethyl acrylate and 3-butyn-1-ol, as key reactions.Similarly, nordehydro-α-matrinidine was synthesized through four steps from 8-bromo-1,6-naphthyridine, obtained by the bromination of unsubstituted 1,6-naphthyridine.Keywords - synthesis; matrine; didehydromatrine; nordehydro-α-matrinidine; palladium-catalyzed reaction; 1,6-naphthyridine; ethyl acrylate; 3-butyn-1-ol