107485-43-8 Usage
General Description
2-Chloro-6-methoxybenzamide is a chemical compound with the molecular formula C8H8ClNO2. It is a white solid that is soluble in organic solvents but sparingly soluble in water. 2-Chloro-6-methoxybenzamide is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also known for its use as an intermediate in the production of dyes and pigments. 2-Chloro-6-methoxybenzamide has also been studied for its potential biological and pharmacological properties, including its antimicrobial and anti-inflammatory activities. Additionally, it has been investigated for its potential as a herbicide and fungicide.
Check Digit Verification of cas no
The CAS Registry Mumber 107485-43-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,4,8 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 107485-43:
(8*1)+(7*0)+(6*7)+(5*4)+(4*8)+(3*5)+(2*4)+(1*3)=128
128 % 10 = 8
So 107485-43-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H8ClNO2/c1-12-6-4-2-3-5(9)7(6)8(10)11/h2-4H,1H3,(H2,10,11)
107485-43-8Relevant articles and documents
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach
Ni, Shuaishuai,Yuan, Yaxia,Huang, Jin,Mao, Xiaona,Lv, Maosheng,Zhu, Jin,Shen, Xu,Pei, Jianfeng,Lai, Luhua,Jiang, Hualiang,Li, Jian
supporting information; experimental part, p. 5295 - 5298 (2010/02/28)
This work describes an integrated approach of de novo drug design, chemical synthesis, and bioassay for quick identification of a series of novel small molecule cyclophilin A (CypA) inhibitors (1-3). The activities of the two most potent CypA inhibitors (3h and 3i) are 2.59 and 1.52 nM, respectively, which are about 16 and 27 times more potent than that of cyclosporin A. This study clearly demonstrates the power of our de novo drug design strategy and the related program LigBuilder 2.0 in drug discovery.
