107485-63-2 Usage
General Description
2-BROMO-6-FLUOROBENZAMIDE is a chemical compound with the molecular formula C7H5BrFNO. It is an organic compound that consists of a benzene ring with a bromine and a fluorine atom attached to it. 2-BROMO-6-FLUOROBENZAMIDE is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the production of dyes and other organic compounds. 2-BROMO-6-FLUOROBENZAMIDE is a white solid that is sparingly soluble in water but is soluble in organic solvents. It has a wide range of applications in the pharmaceutical and chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 107485-63-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,4,8 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 107485-63:
(8*1)+(7*0)+(6*7)+(5*4)+(4*8)+(3*5)+(2*6)+(1*3)=132
132 % 10 = 2
So 107485-63-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H5BrFNO/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H2,10,11)
107485-63-2Relevant articles and documents
Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold
Chen, Weixiong,Chen, Wuhong,Feng, Bo,Han, Sheng,Hu, Youhong,Li, Jia,Wang, Peipei,Zang, Yi
supporting information, (2022/01/14)
The COVID-19 pandemic has drastically impacted global economies and public health. Although vaccine development has been successful, it was not sufficient against more infectious mutant strains including the Delta variant indicating a need for alternative treatment strategies such as small molecular compound development. In this work, a series of SARS-CoV-2 main protease (Mpro) inhibitors were designed and tested based on the active compound from high-throughput diverse compound library screens. The most efficacious compound (16b-3) displayed potent SARS-CoV-2 Mpro inhibition with an IC50 value of 116 nM and selectivity against SARS-CoV-2 Mpro when compared to PLpro and RdRp. This new class of compounds could be used as potential leads for further optimization in anti COVID-19 drug discovery.
