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1075-59-8

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1075-59-8 Usage

Uses

4,?6-?dimethoxy-1,?3,?5-?Triazin-?2(1H)?-?one is a cyanuric acid (C987715) derivative and its cationic form is used as a leaving group for the rapid formation of carbocation species in the acid-?catalyzed alkylation of O- and C-?nucleophiles.

Check Digit Verification of cas no

The CAS Registry Mumber 1075-59-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,7 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1075-59:
(6*1)+(5*0)+(4*7)+(3*5)+(2*5)+(1*9)=68
68 % 10 = 8
So 1075-59-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H7N3O3/c1-10-4-6-3(9)7-5(8-4)11-2/h1-2H3,(H,6,7,8,9)

1075-59-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,6-Dimethoxy-1,3,5-triazin-2(1H)-one

1.2 Other means of identification

Product number -
Other names 4,6-dimethoxy-1H-1,3,5-triazin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1075-59-8 SDS

1075-59-8Relevant articles and documents

4,6-dimethoxy-1,3,5-triazin-2-yl-d-glycosaminides: Novel substrates for transglycosylation reaction catalyzed by exo-d-glucosaminidase from amycolatopsis orientalis

Tanaka, Tomonari,Wada, Tomonori,Noguchi, Masato,Ishihara, Masaki,Kobayashi, Atsushi,Ohnuma, Takayuki,Fukamizo, Tamo,Brzezinski, Ryszard,Shoda, Shin-Ichiro

, p. 634 - 646 (2012)

A novel sugar adduct, 4,6-dimethoxy-1,3,5-triazin-2-yl-d-glucosaminide (GlcN-DMT), has been prepared by the reaction of d-glucosamine (GlcN) and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-morpholinium chloride (DMT-MM). The adduct was recognized by exo-d-glucosaminidase (GlcNase) from Amycolatopsis orientalis and transferred the GlcN moiety, giving rise to the corresponding glucosaminides. This chemo-enzymatic process was successfully applied to d-galactosamine (GalN). GalN-DMT prepared directly from GalN and DMT-MM behaved as an efficient glycosyl donor for transfer of the GalN moiety catalyzed by the same enzyme. The introduction of the 4,6-dimethoxy-1,3,5-triazin-2-yl leaving group to the anomeric center significantly enhanced transglycosylating ability, resulting in the efficient glycosidase-catalyzed synthesis of glycosaminides.

Optimized triazine-mediated amidation for efficient and controlled functionalization of hyaluronic acid

Borke, Tina,Winnik, Fran?oise M.,Tenhu, Heikki,Hietala, Sami

, p. 42 - 50 (2015)

Triazine-based coupling agents have the potential to replace carbodiimides in the functionalization of hyaluronic acid (HA) giving derivatives with high degrees of substitution (DS) under mild conditions with excellent efficiency. Kinetics of the triazine

sym-triazine derivatives. 2. Synthesis, properties, and structure of 2-oxo-1,2-dihydro-sym-triazines

Mikhailichenko,Chesniyuk,Zavodnik,Firgand,Konyushkin,Zaplishny

, p. 292 - 299 (2002)

Previously unreported 2-oxo-1,2-dihydro-sym-triazines have been prepared and their alkylation reactions have been studied. It was found that, independently of the structure and nature of the substituent in positions 4 and 6 of the triazine ring or the str

Nitrogen Kinetic Isotope Effects on the Acylation of Aniline

Kaminski, Z. J.,Paneth, P.,O'Leary, M. H.

, p. 5716 - 5718 (1991)

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USE OF A L,3J5-TRIAZIN-2-YL PHOSPHORAMIDATE COMPOUND IN THE SYNTHESIS OF SOFOSBUVIR

-

Page/Page column 14, (2015/11/09)

The present invention relates to a new type of 1,3.5-triazin-2-yl phosphoramidates of general formula I with the absolute configuration (S) at the phosphorus atom, an Sp diastereoisomer, wherein R1 and R2 can independently be H, a C1-C6 (un)branched alkyl, a C1-C6 (un)branched alkoxy group, a C1-C6 (un)branched alkylsulfanyl group, C1-C6 (un)branched monoalkylamino or dialkylamino group, including cyclic amino groups, e.g. pyrrolidino, piperidino or morpholino group; and to their use for the production of biologically active phosphoramidate prodrugs, especially sofosbuvir of formula II. Sofosbuvir II is a nucleotide inhibitor of the RNA polymerase, used for the treatment of hepatitis C in the form of a prodrug, releasing the active antiviral agent 2'-deoxy-2'-a-fluoro- P-C-methyluridine-5'-triphosphate in the organism.

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