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107504-08-5

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107504-08-5 Usage

Synthesis

Potassium phosphate monobasic (1.4 g, 10 mmol) in water (10 mL) was added to a solution of 5-fluoropyridine-2-carbaldehyde (0.50 g, 4.0 mmol, Frontier) in DMSO (10 mL). Sodium chlorite (0.9 g, 0.008 mol) in water (10 mL) was added, and the reaction continued for 1 hour. The mixture was saturated with NaCl, then diluted with EtOAc. The organic layer was further washed with brine, dried over sodium sulfate and concentrated to afford 5-FLUORO-2-PICOLINIC ACID (370 mg, 65%).

Check Digit Verification of cas no

The CAS Registry Mumber 107504-08-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,5,0 and 4 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 107504-08:
(8*1)+(7*0)+(6*7)+(5*5)+(4*0)+(3*4)+(2*0)+(1*8)=95
95 % 10 = 5
So 107504-08-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F4O/c8-5-2-1-3-6(4-5)12-7(9,10)11/h1-4H

107504-08-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (F0838)  5-Fluoro-2-pyridinecarboxylic Acid  >98.0%(GC)(T)

  • 107504-08-5

  • 1g

  • 690.00CNY

  • Detail
  • TCI America

  • (F0838)  5-Fluoro-2-pyridinecarboxylic Acid  >98.0%(GC)(T)

  • 107504-08-5

  • 5g

  • 1,990.00CNY

  • Detail
  • Alfa Aesar

  • (H32086)  5-Fluoropyridine-2-carboxylic acid, 97%   

  • 107504-08-5

  • 250mg

  • 767.0CNY

  • Detail
  • Alfa Aesar

  • (H32086)  5-Fluoropyridine-2-carboxylic acid, 97%   

  • 107504-08-5

  • 1g

  • 2125.0CNY

  • Detail

107504-08-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Fluoropicolinic acid

1.2 Other means of identification

Product number -
Other names 5-Fluoro-2-pyridinecarboxylic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107504-08-5 SDS

107504-08-5Relevant articles and documents

Improved Process for a Copper-Catalyzed C-N Coupling in the Synthesis of Verubecestat

Phillips, Eric M.,Reibarkh, Mikhail,Limanto, John,Kieu, Minh,Lekhal, Azzeddine,Zewge, Daniel

, p. 1674 - 1678 (2019)

Verubecestat is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor which was previously evaluated for the treatment of Alzheimer's disease. The synthesis of verubecestat relies on a Cu-catalyzed carbon-nitrogen coupling. During process development, observations of impurity formation led to a more robust understanding of the catalyst. The transformation was discovered to be highly dependent on the ratio of ligand to substrate concentration during the course of the reaction. In-depth studies aimed at attaining mechanistic understanding provided an explanation of experimental findings and ultimately led to the identification of conditions that resulted in a more robust process.

HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-D]PYRIMIDINES AS JANUS KINASE INHIBITORS

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Page/Page column 85; 86, (2011/04/14)

The present invention provides heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3 djpyrimidines of Formula Ia or a pharmaceutically acceptable salt thereof; wherein: A is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-I4 cycloalkyl, C2-13 heterocycloalkyl, C6-14 aryl, C1-14 heteroaryl, C3-14 cycloalkyl-C1-4 alkyl, C2-13 heterocycloalkyl-C1-4 alkyl, C6-14 aryl-C1-4 alkyl, or C14 heteroaryl-C14 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-14 cycloalkyl, C2-13 heterocycloalkyl, C6-14 aryl, C1-14 heteroaryl, C3-14 cycloalkyl-C1-4 alkyl, C2-13 heterocycloalkyl-C1-4 alkyl, C6-14 aryl-C1-4 alkyl, and C1-14 heteroaryl-C1-4 alkyl are each optionally substituted with I, 2, 3, 4, 5, or 6 independently selected R8 substituents; L is absent, C(=O), C(=O)NH, S(=O), or S(O)2; X is CH or N; Y is H, cyano, halo, C1-4 alkyl, or C1-4 haloalkyl; Z is CR7 or N; R1, R2, and R3 are each independently H, hydroxyl, halo, C1-3 alkyl, or C1-3 haloalkyl; R4 and R5 are each independently H, C1-3 alkyl, or C1-3 haloalkyl; or R4 and R5 together with the carbon atom to which they are attached can form a 3-, 4-, 5-, 6- υr 7-membered cycloalkyl ring; as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example inflammatory disorders, autoimmune disorders, cancer, and other diseases.

FIVE-MEMBERED HETEROCYCLIC DERIVATIVE

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Page/Page column 58, (2010/11/08)

The present invention relates to a compound represented by formula (I): a salt of the compound, or a solvate of the compound or the salt; a drug containing any of the compounds, the salts, and the solvates; a preventive and/or therapeutic agent for an ischemic disease containing any of the compounds, the salts, and the solvates; and a platelet coagulation inhibitor containing any of the compounds, the salts, and the solvates. The compound of the present invention is useful as a strong platelet coagulation inhibitor without inhibiting COX-1 or COX-2.

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