107514-60-3Relevant academic research and scientific papers
Novel Cyclization of S-(o-Acetylaryl) Dimethylthiocarbamates. A New Synthesis of 3-Hydroxybenzothiophenes and 2-Hydroxythiochromones
Lau, C.K.,Belanger, Patrice C.,Dufresne, C.,Scheigetz, J.
, p. 1670 - 1673 (1987)
The rearrangement of O-(o-acetylaryl) dimethylthiocarbamates to their corresponding S-aryl dimethylthiocarbamates, previously reported to be a very low yielding reaction, have been achieved in acceptable yields.The versatility of these intermediates is demonstrated by their transformation into different heterocyclic systems.Thus, when the resulting S-(acetylaryl) dimethylthiocarbamates are treated with base in the presence of air, they cyclize in a novel fashio to yield substituted N,N-dimethyl-3-hydroxybenzothiophene-2-carboxamides and substituted 2-hydroxythiochromones.In the absence of air, only the latter was formed.
