1075181-20-2

Upstream product

• 434951-37-8 N-(4-methoxyphenyl)-1-(m-tolyl)ethan-1-imine 
• 104-94-9 4-methoxy-aniline 
• 585-74-0 3-Methylacetophenone 
• 7287-81-2 1-(m-methylphenyl)ethanol 

Relevant academic research and scientific papers

A chiral borane catalyzed asymmetric hydrosilylation of imines

An enantioselectiveusing a chiral borane catalyst generated by the in situ hydroboration of a binaphthyl-based chiral diene with Piers' borane HB(C6F5)2 to furnish a variety of optically active amines in 70% to >99% yields

Chiral cyclometalated iridium complexes for asymmetric reduction reactions

A series of chiral cyclometalated iridium complexes have been synthesised by cyclometalating chiral 2-aryl-oxazoline and imidazoline ligands with [Cp?IrCl2]2. These iridacycles were studied for asymmetric transfer hydrogenation reactions with formic acid as the hydrogen source and were found to display various activities and enantioselectivities, with the most effective ones affording up to 63% ee in the asymmetric reductive amination of ketones and 77% ee in the reduction of pyridinium ions. This journal is

Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control

An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key t

Catalytic enantioselective amination of alcohols by the use of borrowing hydrogen methodology: Cooperative catalysis by iridium and a chiral phosphoric acid

The catalytic asymmetric reduction of ketimines has been explored extensively for the synthesis of chiral amines, with reductants ranging from Hantzsch esters, silanes, and formic acid to H2 gas. Alternatively, the amination of alcohols by the use of borrowing hydrogen methodology has proven a highly atom economical and green method for the production of amines without an external reductant, as the alcohol substrate serves as the H2 donor. A catalytic enantioselective variant of this process for the synthesis of chiral amines, however, was not known. We have examined various transition- metal complexes supported by chiral ligands known for asymmetriC-Hydrogenation reactions, in combination with chiral Bronsted acids, which proved essential for the formation of the imine intermediate and the transfer-hydrogenation step. Our studies led to an asymmetric amination of alcohols to provide access to a wide range of chiral amines with good to excellent enantioselectivity.

Cooperative catalysis: Combining an achiral metal catalyst with a chiral Br?nsted acid enables highly enantioselective hydrogenation of imines

Asymmetric hydrogenation of imines leads directly to chiral amines, one of the most important structural units in chemical products, from pharmaceuticals to materials. However, highly effective catalysts are rare. This article reveals that combining an ac

Chiral counteranion-aided asymmetric hydrogenation of acyclic imines

When combined with a chiral phosphate counteranion, a chiral diamine-ligated Ir(III) catalyst displayed excellent enantioselectivities in the asymmetric hydrogenation of a wide range of acyclic imines, affording chiral amines in up to 99% ee. Copyright