1075200-52-0Relevant academic research and scientific papers
Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts
Eiseman, Julie L.,Bai, Lihua,Jung, Won-Hyuk,Moura-Letts, Gustavo,Day, Billy W.,Curran, Dennis P.
supporting information; experimental part, p. 6650 - 6653 (2009/10/23)
Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.
