1075215-63-2

Upstream product

• 1051899-86-5 [3-[(2-chloropyrimidin-4-yl)-methyl-amino]-4-methyl-phenyl]methanol 
• 1075215-74-5 2,6-dimorpholin-4-ylpyridin-4-amine 
• 1075215-77-8 2-chloro-N-[5-[(dimethyl-tert-butyl-silyl)oxymethyl]-2-methyl-phenyl]-N-methyl-pyrimidin-4-amine 

Relevant academic research and scientific papers

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

Optimization of our bis-anilino-pyrimidine series of EphB4 kinase inhibitors led to the discovery of compound 12 which incorporates a key m-hydroxymethylene group on the C4 aniline. 12 displays a good kinase selectivity profile, good physical properties a

N' - (PHENYL) -N- (MORPHOLIN-4-YL-PYRIDIN-2-YL) -PYRIMIDINE-2, 4-DIAMINE DERIVATIVES AS EPHB4 KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE CONDITIONS

The invention concerns pyrimidine com pounds of Formula (I), or a pharmaceutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 are as defined in the descripti