1075238-97-9Relevant academic research and scientific papers
Copper-catalyzed intramolecular N-vinylation of sulfonamides: General and efficient synthesis of heterocyclic enamines and macrolactams
Lu, Hongjian,Yuan, Xinting,Zhu, Shana,Sun, Changhui,Li, Chaozhong
experimental part, p. 8665 - 8668 (2009/04/11)
(Chemical Equation Presented) With the catalysis of CuI/N,N′- dimethylethylenediamine, intramolecular C-N coupling between sulfonamides and vinyl halides was successfully implemented, leading to the efficient synthesis of 5-, 6-, 7-, and even 8-membered heterocyclic enamines in both exo and endo modes. The bicyclic enamines thus formed provided a convenient entry to the corresponding 9- to 12-membered lactams by oxidative C=C bond cleavage.
