1075239-91-6Relevant academic research and scientific papers
Second-generation, biomimetic total synthesis of chaetominine
Coste, Alexis,Karthikeyan, Ganesan,Couty, Francois,Evano, Gwilherm
experimental part, p. 2927 - 2934 (2010/03/25)
A straightforward total synthesis of the potent anticancer agent (-)-chaetominine is reported. Central to this synthesis was a biomimetic oxidative cyclization of a tryptophanyl-alanine dipeptide, which provided a fully elaborated 1,2,3,4-tetrahydropyrido[ 2,3-b]indole. Reduction of this intermediate followed by spontaneous cyclization and installation of the side chain provided synthetic chaetominine in a nine-step sequence in 14% overall yield starting from commercially available, inexpensive starting materials. Georg Thieme Verlag Stuttgart.
Total synthesis of chaetominine
Toumi, Mathieu,Couty, Francois,Marrot, Jerome,Evano, Gwilherm
supporting information; experimental part, p. 5027 - 5030 (2009/05/07)
(Figure Presented) An efficient, asymmetric synthesis of the cytotoxic natural product chaetominine was achieved in 14 steps. The strategy employs a copper(I)-mediated cyclization reaction as a key step to install the abc-tricyclic ring system, which was
