1075240-37-7

Basic information

• Product Name: C₃₁H₄₂N₄O₈
• CAS NO: 1075240-37-7
• Molecular Weight: 598.696
• Mol File: 1075240-37-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₄₂N₄O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₄₂N₄O₈(1075240-37-7)
• EPA Substance Registry System: C₃₁H₄₂N₄O₈(1075240-37-7)

Safety Data

• Hazardous Substances Data: 1075240-37-7(Hazardous Substances Data)

Upstream product

• 1075240-47-9 C₁₀H₁₉NO₃ 
• 13614-98-7 minocycline Hydrochloride 

Relevant articles and documents

Synthesis development of an aminomethylcycline antibiotic via an electronically tuned acyliminium Friedel-Crafts reaction

With the goal of improving the synthetic efficiency, the development of a convergent synthesis of a minocycline derivative PTK0796 via an intermolecular acyliminium Friedel-Crafts reaction (Tscherniac-Einhorn reaction) is described. The entire C9 neopentylaminomethyl side chain was installed in one step using an electronically optimized chloromethylacyliminium precursor in 83% yield. Deprotection and re-equilibration to the C4 α-epimer in the presence of CaCl2 and ethanolamine or NaOH afforded the target aminomethylcycline antibiotic. The corresponding crystalline tosylate salt was found to exhibit improved solid state stability.