107537-99-5

Basic information

• Product Name: Pentanenitrile, 2-hydroxy-, (S)-
• CAS NO: 107537-99-5
• Molecular Formula: C5H9NO
• Molecular Weight: 99.1326
• Mol File: 107537-99-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Pentanenitrile, 2-hydroxy-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanenitrile, 2-hydroxy-, (S)-(107537-99-5)
• EPA Substance Registry System: Pentanenitrile, 2-hydroxy-, (S)-(107537-99-5)

Safety Data

• Hazardous Substances Data: 107537-99-5(Hazardous Substances Data)

Upstream product

• 123-72-8 butyraldehyde 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 74-90-8 hydrogen cyanide 
• 127-08-2 potassium acetate 
• 98-59-9 p-toluenesulfonyl chloride 
• 773837-37-9 sodium cyanide 
• 2983-06-4 2-acetoxybutanenitrile 
• 4111-12-0 (+/-)-2-methyl-2-hydroxyhexanenitrile 
• 129313-22-0 (S)-2-(Butyryloxy)pentannitril 
• 129265-86-7 2-(Butyryloxy)pentannitril 
• 129265-91-4 2-(Phenylpropionyloxy)pentannitril 
• 129265-90-3 2-(Phenylacetoxy)pentannitril 

Relevant articles and documents

Aliphatic (S)-Cyanohydrins by Enzyme Catalyzed Synthesis

The enzyme catalyzed synthesis of aliphatic (S)-cyanohydrins has been accomplished for the first time by application of a hydroxynitrile lyase from leaves of Hevea brasiliensis.The optical purities of (S)-cyanohydrins obtained are in a range between 60 - 97percent.

A simple separation method for (S)-hydroxynitrile lyase from cassava and its application in asymmetric cyanohydrination

Using an acetone precipitation method, crude (S)-hydroxynitrile lyase [(S)-MeHNL] was separated from Munihot esculenta (cassava) leaves, and used directly as biocatalyst to catalyze asymmetric cyanohydrination and produce cyanohydrins with enantiomeric purities (≥90% ee) significantly greater than those previously reported. The use of a water/i-Pr2O system with an enzyme, NaCN, and appropriate amounts of acetic acid is crucial in improving the stereoselectivity of cyanohydrin formation by minimizing the non-enzymatic reaction and the racemization of the chiral products. The proposed isolation method for crude (S)-MeHNL has a high value because of its simplicity, and low cost as well as the high activity of the crude (S)-MeHNL.

Approach to (R)- and (S)-ketone cyanohydrins using almond and apple meal as the source of (R)-oxynitrilase

The synthesis of aliphatic and aromatic (R)-ketone cyanohydrins through the addition of hydrogen cyanide to the corresponding ketones and the synthesis of the (S)-enantiomers through the kinetic resolution of racemic ketone cyanohydrins has been studied in the presence of almond or apple meal. Substrate tolerance of the (R)-oxynitrilases towards ketones (R1R2C=O) is highly restricted compared to that of structurally similar aldehydes, reactivity following the order of H>Me>>Et for R2. In the case of aromatic methyl ketones reactivity difference (C6H5>>p-Me-C6H4 for R1) is notable.