107549-70-2

Upstream product

• 107549-84-8 3-Methyl-4-oxo-4-[4-(6-oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-butyric acid 
• 126725-05-1 6-<4-<3-(dimethylamino)-2-methylpropionyl>phenyl>pyridazin-3(2H)-one hydrochloride 
• 107549-83-7 6-<4-(3-cyano-2-methylpropionyl)phenyl>pyridazin-3-(2H)-one 
• 107549-81-5 6-(4-propionylphenyl)pyridazin-3(2H)-one 
• 107549-80-4 6-(4-propylphenyl)pyridazin-3(2H)-one 

Relevant academic research and scientific papers

Benzene compounds having two pyridazinone substituents

The invention relates to pyridazinone derivatives which have inotropic, vasodilator and bronchodilator activity. The compounds of the invention are described by formula (I): STR1 wherein: R1 is hydrogen or methyl; R2 is hydrogen or methyl; and represent double or single bonds; and the benzene ring is para- or meta-substituted; and pharmaceutically acceptable salts thereof.

1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene Analogues: Potent Phosphodiesterase Inhibitors and Inodilators

1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene and a series of related bis(azinone) compounds were synthesized.These novel compounds were evaluated for inhibition of the low Km, cAMP-selective, cGMP-inhibited phosphodiesterase (PDE III) derive