107558-43-0Relevant articles and documents
A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus–Silane System
Schoene, Jens,Bel Abed, Hassen,Schmieder, Peter,Christmann, Mathias,Nazaré, Marc
, p. 9090 - 9100 (2018)
A simple and direct approach for the regioselective construction of the privileged 2H-indazole scaffold is described. The developed one-pot strategy involves phospholene-mediated N?N bond formation to access 2H-indazoles. The amount of organophosphorus reagent was minimized by recycling the phospholene oxide with organosilane reductants. Starting from functionalized 2-nitrobenzaldehydes and primary amines, a mild reductive cyclization, involving the use of commercially available phospholene oxide and silanes, delivered a wide variety of substituted 2H-indazoles in good to excellent yields.