107563-01-9

Upstream product

• 2727-68-6 2,2,2-trifluoro-N-o-tolylacetamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 20939-81-5 2,2,2-Trifluoro-N-(2-hydroxymethyl-phenyl)-acetamide 

Downstream Products

• 1010707-07-9 methyl 4-m-tolyl-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-08-0 methyl 4-(4-methoxyphenyl)-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-14-8 C₁₉H₁₈BrF₃N₂O₃ 
• 1010707-15-9 C₁₉H₁₈BrF₃N₂O₃ 
• 1010707-13-7 N-[2-(anilinomethyl)phenyl]trifluoroacetamide 
• 1010707-03-5 methyl 4-phenyl-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-05-7 methyl 4-(4-chlorophenyl)-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-06-8 methyl 4-p-tolyl-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-04-6 methyl 4-(4-fluorophenyl)-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 

Relevant academic research and scientific papers

A synthesis of functionalized indoline 2,2-biscarboxylates

A synthetic approach to a structurally novel series of indoline 2,2-biscarboxylates is described that employs a tandem bis-alkylation strategy to cyclize the indoline heteroring from the bromide 7 and diethyl bromomalonate. The indolines thus prepared may be N-deprotected and further functionalized on the indoline nitrogen.

Novel indole-ring formation by thermolysis of 2-(N-acylamino)benzylphosphonium salts. Effective synthesis of 2-trifluoromethylindoles

Thermolysis of 2-(N-acylamino)benzyl methyl ethers, in the presence of an acid catalyst and triphenylphosphine, or 2-(N-acylamino)benzylphosphonium salts is found to serve as a novel method for indole formation, in particular for the synthesis of 2-trifluoromethylindoles. The reaction of the benzyl methyl ethers is suggested to involve a phosphonium intermediate, which thermally decomposes to the indoles.