1075710-22-3

Upstream product

• 1075710-16-5 C₁₆H₂₇Cl₃N₂O₅ 
• 1239981-43-1 C₁₁H₁₉Cl₃N₂O₃*ClH 
• 1075710-17-6 C₂₆H₃₈Cl₃N₃O₆ 
• 1239985-33-1 C₂₁H₃₀Cl₃N₃O₄*ClH 
• 1075710-18-7 C₂₉H₄₃Cl₃N₄O₇ 
• 1352449-33-2 C₂₄H₃₅Cl₃N₄O₅*ClH 
• 1075710-20-1 C₅₁H₈₃Cl₃N₄O₁₀SSi 
• 1352449-18-3 C₄₅H₆₉Cl₃N₄O₁₀S 
• 1075710-21-2 C₆₃H₈₄Cl₃N₅O₁₃S 
• 1352449-55-8 C₆₁H₈₃N₅O₁₃S 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 
• 1239981-42-0 C₁₃H₂₂Cl₃NO₄ 
• 1075710-19-8 C₃₀H₄₅Cl₃N₄O₇ 

Downstream Products

• 1352449-57-0 C₄₆H₇₁N₅O₁₀S 
• 1009642-78-7 C₄₄H₆₇N₅O₁₀ 

Relevant academic research and scientific papers

The total synthesis and structure-activity relationships of a highly cytotoxic depsipeptide kulokekahilide-2 and its analogs

We successfully completed the total synthesis of kulokekahilide-2, a cytotoxic depsipeptide from the Cephalaspiedean mollusk Phillinopsis speciosa. We have revised the absolute stereochemistry of kulokekahilide-2 to 21-l-Ala, 24-d-MePhe, 37-l-Ile, 43-d-Ala, 15-d-Hica, and 5S,6S,7S-Dtda. We also investigated the cause of the mis-assignment of the configuration in the originally proposed kulokekahilide-2 and concluded that methanolysis using MeONa caused partial racemization, which led to the mis-assignment. The structure-activity relationships of kulokekahilide-2 and its analogs indicate the importance of an l-amino acid at position 21.