1075715-57-9

Basic information

• Product Name: (S)-1-(3-CHLOROPHENYL)PROPAN-1-AMINE
• Synonyms: (S)-1-(3-CHLOROPHENYL)PROPAN-1-AMINE;(S)-1-(3-CHLORO-PHENYL)-PROPYLAMINE;Benzenemethanamine, 3-chloro-.alpha.-ethyl-, (.alpha.S)-;(S)-1-(3-Chlorophenyl)propan-1-aMine hydrochloride;(S)-1-(3-CHLOROPHENYL)PROPAN-1-AMINE-HCl;1-(3-chlorophenyl)propylamine;(1S)-1-(3-chlorophenyl)propan-1-amine
• CAS NO: 1075715-57-9
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.65
• Mol File: 1075715-57-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-1-(3-CHLOROPHENYL)PROPAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3-CHLOROPHENYL)PROPAN-1-AMINE(1075715-57-9)
• EPA Substance Registry System: (S)-1-(3-CHLOROPHENYL)PROPAN-1-AMINE(1075715-57-9)

Safety Data

• Hazardous Substances Data: 1075715-57-9(Hazardous Substances Data)

Usage

General Description

(S)-1-(3-chlorophenyl)propan-1-amine is a chemical compound with the formula C9H12ClN. It is a chiral amine, meaning it has two enantiomers that are non-superimposable mirror images of each other. It is commonly used in the synthesis of various pharmaceuticals and drug compounds due to its versatile reactivity and potential therapeutic applications. The presence of a chiral center in the molecule gives it important biological activity and pharmacological properties. It is primarily used as a building block in organic synthesis and drug development, and its stereochemistry plays a crucial role in its interactions with biological targets. Additionally, it has potential applications in the treatment of neurological and psychiatric disorders, such as depression and anxiety.

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 925-90-6 ethylmagnesium bromide 
• 587-04-2 m-Chlorobenzaldehyde 
• 34841-35-5 3'-chloro-propiophenone 

Relevant articles and documents

Kinetic Resolution of Benzylamines via Palladium(II)-Catalyzed C-H Cross-Coupling

A Pd(II)-catalyzed enantioselective C-H cross-coupling of benzylamines via kinetic resolution has been achieved using chiral mono-N-protected α-amino-O-methylhydroxamic acid (MPAHA) ligands. Both chiral benzylamines and ortho-arylated benzylamines are obtained in high enantiomeric purity. The use of a readily removable nosyl (Ns) protected amino group as the directing group is a crucial practical advantage. Moreover, the ortho-arylated benzylamine products could be further transformed into chiral 6-substituted 5,6-dihydrophenanthridines as important structural motifs in natural products and bioactive molecules.

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.