1075720-86-3Relevant academic research and scientific papers
Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: Cyclopropane-based conformationally restricted analogs of haloperidol
Yamaguchi, Kazuya,Kazuta, Yuji,Hirano, Kazufumi,Yamada, Shizuo,Matsuda, Akira,Shuto, Satoshi
experimental part, p. 8875 - 8881 (2009/04/11)
A series of the cyclopropane-based conformationally restricted analogs of haloperidol were designed as potential antidopaminergic agents and were effectively synthesized using highly stereoselective Grignard reaction with tert-butanesulfinyl imines as the key step. Pharmacological evaluation of the compounds showed that the conformational restriction method can effectively work for improving the pharmacological selectivity of a parent compound and also for investigating the bioactive conformation.
