1075736-54-7

Basic information

• Product Name: C₁₉H₂₉ClN₄O
• CAS NO: 1075736-54-7
• Molecular Weight: 364.918
• Mol File: 1075736-54-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₉ClN₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₉ClN₄O(1075736-54-7)
• EPA Substance Registry System: C₁₉H₂₉ClN₄O(1075736-54-7)

Safety Data

• Hazardous Substances Data: 1075736-54-7(Hazardous Substances Data)

Upstream product

• 39512-50-0 N-(o-Chlorophenyl)piperazine 
• 936691-71-3 C₉H₁₇ClN₂O 

Relevant articles and documents

Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists

Spiro-isobenzofuranones 1a and 1b were discovered as potent, selective, and brain-penetrable non-imidazole H3 receptor inverse agonists. Our corporate sample collection was screened to identify 2a as a lead. Recognizing the right-hand portion of 2a as an essential pharmacophore, an extensive screen of the left-hand piperidine portion was carried out to yield the potent spiro-derivatives 2t-x. Spiro-isobenzofuranone 2x, the most potent among the derivatives, was converted to the corresponding amide 1a, which possessed dramatically improved H3 activity (IC50 = 0.72 nM; more than 20-fold improvement over 2x). Further elaboration led to the identification of 1b, a 5-methoxy derivative with an IC50 of 0.54 nM. Our studies demonstrated that derivatives 1a and 1b to be potent, selective, and brain-penetrable H3 inverse agonists.