1075749-63-1

Basic information

• Product Name: C₂₂H₁₈FNO₈S
• Synonyms: C₂₂H₁₈FNO₈S
• CAS NO: 1075749-63-1
• Molecular Weight: 475.451
• Mol File: 1075749-63-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈FNO₈S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈FNO₈S(1075749-63-1)
• EPA Substance Registry System: C₂₂H₁₈FNO₈S(1075749-63-1)

Safety Data

• Hazardous Substances Data: 1075749-63-1(Hazardous Substances Data)

Upstream product

• 1075749-58-4 C₁₅H₁₄FNO₄ 
• 4025-64-3 3-Carboxybenzenesulfonyl chloride 

Downstream Products

• 1075749-92-6 C₂₀H₁₄FNO₇S 

Relevant articles and documents

Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: Heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

Heat shock protein 90 is emerging as an important target in cancer chemotherapy. In a program directed toward identifying novel chemical probes for Hsp90, we found N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)benzene sulfonamide as an Hsp90 inhibitor with very weak activity. In this report, we present a new and general method for the synthesis of a variety of analogs around this scaffold, and discuss their structure-activity relationships.