107599-99-5Relevant articles and documents
Renin Inhibitors. Design of Angiotensinogen Transition-State Analogues Containing Novel (2R,3R,4R,5S)-5-Amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic Acid
Thaisrivongs, Suvit,Pals, Donald T.,Kroll, Lisa T.,Turner, Steve R.,Han, Fu-Son
, p. 976 - 982 (1987)
A highly stereoselective synthesis of 2(R)--3-methylbutyl>-2,2-dimethyl-4(R)-dioxolanyl>-3-methylbutanoic acid (11) is described.This is a suitably protected carboxylic acid useful as an intermediate for the prepa
Conformational preference in bis(porphyrin) tweezer complexes: A versatile chirality sensor for α-chiral carboxylic acids
Tanasova, Marina,Borhan, Babak
supporting information; experimental part, p. 3261 - 3269 (2012/07/01)
Metallated porphyrin tweezers have demonstrated a remarkable ability to function as reporters of absolute stereochemistry for a number of different classes of organic molecules. Flexibility in binding, however, can result in an ensemble of different Exciton Coupled Circular Dichroism (ECCD) active conformations that could lead to variable results. Linker flexibility was found to be a key determinant of binding conformation. Experimental results indicate that a balance between linker flexibility and rigidity could yield an optimum porphyrin tweezer that stabilizes a common conformation for all bound chiral guests. This leads to a more simplified approach to absolute stereochemical determination of asymmetry for small organic molecules. This was demonstrated by the use of a C3-linked zincated porphyrin tweezer that yields a common conformational preference for a variety of α-chiral carboxylic acids derivatized with a diamine carrier. Copyright
Novel gamma-lactams as beta-secretase inhibitors
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Page/Page column 19, (2010/10/20)
There is provided a series of novel substituted gamma-lactams of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, R5 and R6 as defined herein, their ph