107618-03-1Relevant articles and documents
Synthesis method of 1-piperidin-4-yl-1,3-dihydro-imidazol[4, 5-b]pyridine-2-one
-
, (2017/04/03)
The invention discloses a synthesis method of 1-piperidin-4-yl-1,3-dihydro-imidazol[4, 5-b]pyridine-2-one. With 4-piperidone hydrochloride as a start raw material, the synthesis method comprises the following steps: reacting to generate N-t-butyloxycarboryl-4-piperidone and 4-amino-1-t-butyloxycarboryl piperidine; and finally, performing a Curtius rearrangement reaction between 2-(4-amino)piperidyl-3-pyridine carboxylic acid and an azide reagent to obtain a compound 1-piperidin-4-yl-1,3-dihydro-imidazol[4, 5-b]pyridine-2-one of formula V. The synthesis method has the advantages of low cost, easiness in operation, safety, greenness and high yield and can be applied to industrial expanded production.
Dipeptides which promote release of growth hormone
-
, (2008/06/13)
Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis. STR1