1076202-53-3Relevant academic research and scientific papers
Iron-catalyzed C-C bond cleavage and C-N bond formation
Li, Wenjuan,Zheng, Xiaojian,Li, Zhiping
, p. 181 - 190 (2013/03/13)
A novel approach for C-N bond formation was developed by iron-catalyzed C-C bond cleavage. Anilines and sulfonamides reacted smoothly with 2-substituted 1,3-diphenylpropane-1,3-diones to afford N-alkylation products, in which the 1,3-dicarbonyl group acts as a leaving group in the presence of an iron catalyst. The reversible C-C bond cleavage plays a driving force to give the thermodynamically stable products. The method is complementary to the previous methods for C-N bond formation. Copyright
Chiral diphosphane- and NHC-containing ruthenium catalysts for the catalytic asymmetric arylation of aldimines with organoboron reagents
Marques, Carolina S.,Burke, Anthony J.
experimental part, p. 4232 - 4239 (2012/09/22)
For the first time, we report the application of [RuCl2(η 6-p-cymene)]2 in the arylation of N-activated aldimines with boronic acids and its derivatives to afford chiral amines, which are important intermediates in the syntheses of key bioactive compounds. The behavior of the chiral ligands, the imine substrates, and the organoboron reagents were studied. Very good enantioselectivities were obtained. A new method is presented for the synthesis of chiral substituted amines by employing Ru catalysts along with known chiral phosphane ligands and a new NHC-type chiral ligand. Organoboron reagents were applied as the aryl transfer agents. High enantioselectivities were achieved with this new method, and some mechanistic insights are provided.
Phosphotungstic acid catalyzed amidation of alcohols
Wang, Guan-Wu,Shen, Ye-Bing,Wu, Xue-Liang
experimental part, p. 4367 - 4371 (2009/04/14)
Mild nucleophilic substitution reactions of benzhydrylic, benzylic, allylic, and simple aliphatic alcohols with sulfonamides, benzamide, and 4-nitroaniline in the presence of 12-phosphotungstic acid as an efficient, eco-friendly, cheap, and air- and moisture-tolerant catalyst for the construction of C-N bonds has been investigated. The amine derivatives were obtained in good yields (up to 98%). The reusable nature of the 12-phosphotungstic acid makes this protocol more attractive. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
