1076245-91-4

Upstream product

• 1076245-92-5 3-(methoxymethyl)isoxazole-4-carboxylic acid methyl ester 
• 1076245-93-6 3-(methoxymethyl)isoxazole-5-carboxylic acid methyl ester 
• 1401727-21-6 3-methoxymethylisoxazole-5-carboxylic acid ethyl ester 

Downstream Products

• 1076245-62-9 N-{6-amino-5-[2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-3-(methoxymethyl)isoxazole-4-carboxamide 
• 1076245-63-0 N-{6-amino-5-[5-chloro-2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-3-(methoxymethyl)isoxazole-4-carboxamide 
• 1076245-64-1 N-{6-amino-5-[5-fluoro-2-(trifluoromethyl)phenyl]pyrazin-2-yl}-3-(methoxymethyl)isoxazole-4-carboxamide 

Relevant academic research and scientific papers

Positive allosteric modulators of nicotinic acetylcholine receptor

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

N- [6-AMINO-S- (PHENYL) PYRAZIN-2-YL] -ISOXAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NAV1.8 CHANNEL MODULATORS FOR THE TREATMENT OF PAIN

The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.

PYRIDINE DERIVATIVES

The present invention relates to compounds of the formula (I): (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.