107640-46-0

Upstream product

• 107640-45-9 2-(benzyloxycarbonyl)-N,N,2-trimethylpropionamid 
• 15030-72-5 Z-Aib-OH 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 81837-96-9 N-<1-(N,N-Dimethylthiocarbamoyl)-1-methylethyl>benzamid 
• 107640-48-2 N-<1-(N,N-Dimethylthiocarbamoyl)-1-methylethyl>-p-nitrobenzamid 
• 107640-49-3 N-<1-(N,N-Dimethylthiocarbamoyl)-1-methylethyl>-p-methoxybenzamid 

Relevant academic research and scientific papers

2,4-Bis(4-methylphenylthio)-1,3,2λ5,4λ5-dithiadiphosphetane-2,4-dithione: A New Reagent for Thiation of N,N-Disubstituted Amides

As a new reagent for the thiation of amides, the easily accessible 2,4-bis(4-methylphenylthio)-1,3,2λ5,4λ5-dithiadiphosphetane-2,4-dithione (9) shows a remarkable selectivity.This selectivity - the preferred thiation of N,N-disubstituted amides - is complementary to the one of the well known Lawesson reagent.Thiation of diamides of type 2 with 9 leads via cyclization of the corresponding dithiodiamides directly to 1,3-thiazole-5(4H)-thiones 1.

Synthesis of 4,4-Disubstituted 1,3-Thiazol-5(4H)-thiones

An easy synthesis for the 1,3-thiazol-5(4H)-thiones 5, a class of heterocycles which have hitherto only been available with difficulty, is described.Reaction of 3-amino-2H-azirines 25 with thiocarboxylic acids at 0 deg yields monothiodiamides of type 20 (Scheme 6) which, on treatment with Lawesson reagent at 100 deg, undergo thiation and cyclization to give 5 in good yield.