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107650-20-4

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107650-20-4 Usage

Uses

5-Bromo-2-methyl-3-nitrobenzoic Acid is a reactant in the preparation of EPZ005687 (E592200), a potent and selective inhibitor of EZH2.

Check Digit Verification of cas no

The CAS Registry Mumber 107650-20-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,6,5 and 0 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 107650-20:
(8*1)+(7*0)+(6*7)+(5*6)+(4*5)+(3*0)+(2*2)+(1*0)=104
104 % 10 = 4
So 107650-20-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H6BrNO4/c1-4-6(8(11)12)2-5(9)3-7(4)10(13)14/h2-3H,1H3,(H,11,12)

107650-20-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Bromo-2-methyl-3-nitrobenzoic Acid

1.2 Other means of identification

Product number -
Other names 5-BROMO-2-METHYL-3-NITROBENZOIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107650-20-4 SDS

107650-20-4Relevant articles and documents

SKLB1039 Compound as well as preparation method and application thereof

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Paragraph 0030; 0039-0043, (2021/10/27)

The invention belongs to the technical field of preparation of new compounds, and particularly relates SKLB1039 compound as well as a preparation method and application thereof. The 2 -methyl -3 -nitrobenzoic acid is taken as an initial raw material and is brominated. Esterification, reduction, reductive amination and hydrolysis synthesis 5 - bromo -2 - methyl -3 - (N - ethyl, N - (tetrahydropyran -4 - yl)) aminobenzoic acid. The cyclohexanone serving as a raw material is subjected to catalytic hydrogenation reduction of carbonyl α, acetyl cyclohexanone and cyanopyridone to synthesize 4 - aminomethyl -1 - methyl -5, 6, 7, 8 - tetrahydroisoquinoline -3 (2H) - ketone. Coupling the two to an amide is followed by catalytic coupling with an aryl sheet to give SKLB1039 a compound. SKLB1039 Large-scale preparation technology is provided, operation is easy, the post-treatment purification process is simple, the total route yield is improved, raw materials are easy to purchase, the price is low, and the production cost is greatly reduced.

Design and synthesis of (E)-1,2-diphenylethene-based EZH2 inhibitors

Feng, Qiang,Feng, Zhanzhan,He, Hualong,Hu, Xi,Liu, Zhihao,Teng, Fei,Yu, Luoting,Zhang, Qiangsheng

supporting information, (2020/01/22)

Enhancer of zeste homolog 2 (EZH2) serves as the catalytic subunit of the polycomb repression complex 2 (PRC2), which is implicated in cancer progression metastasis and poor prognosis. Based on our EZH2 inhibitor SKLB1049 with low nanomolar activity, we e

SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE

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Page/Page column 145; 146, (2019/01/21)

The present invention provides compounds of Formula (I) or a subgeneric structure or species thereof, or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof, and methods and compositions for treating or ameliorating abnormal cell pr

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