107653-68-9Relevant academic research and scientific papers
Biosynthesis of Natural Products with a P-C Bond, III. - Synthesis of (R)- and (S)-(2-Aminoethyl)phosphonic Acid and Hydroxylation to (2-Amino-1-hydroxyethyl)phosphonic Acid in Acanthamoeba castellanii (Neff)
Hammerschmidt, Friedrich
, p. 955 - 960 (2007/10/02)
(Benzyloxy)acetaldehyde (4) was reduced to give (S)-(+)-2-(benzyloxy)ethanol (5) by horse liver alcohol dehydrogenase/NAD+/EtOH.This chiral alcohol was transformed into (R)- and (S)-(2-aminoethyl)phosphonic acid (AEP) (13).The enantiomer
BIOSYNTHESIS OF 2-AMINO-1-HYDROXY-ETHYLPHOSPHONIC ACID IN ACANTHAMOEBA CASTELLANII
Hammerschmidt, Friedrich
, p. 575 - 578 (2007/10/02)
The 2-amino-1-hydroxy-ethylphosphonic acid in Acanthamoeba castellanii (Neff) is biosynthesized by hydroxylating 2-amino-ethylphosphonic acid with removal of the C-1 pro-S hydrogen and replacing it by OH with retention of configuration.
