107656-13-3Relevant articles and documents
Biosynthesis of dictyopterene A: Stereoselectivity of a lipoxygenase/hydroperoxide lyase from Gomphonema parvulum (Bacillariophyceae)
Hombeck, Marc,Pohnert, Georg,Boland, Wilhelm
, p. 243 - 244 (1999)
(9S)-Hydroperoxyicosatetraenoic (9S-HPETE) acid is shown to be an intermediate in the biosynthesis of dictyopterene A in the freshwater diatom Gomphonema parvulum; the stereochemistry of (9S)-HPETE and the position of the hydrogen atom at C(16) lost during fatty acid cyclisation and oxidative cleavage of the hydroperoxide were investigated using trapping experiments and chirally deuterium labelled fatty acids.
Repurposing Resveratrol and Fluconazole to Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism
El-Sherbeni, Ahmed A.,El-Kadi, Ayman O. S.
, p. 1278 - 1288 (2016/04/26)
Cytochrome P450 (P450) enzymes metabolize arachidonic acid (AA) to several biologically active epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). Repurposing clinically-approved drugs could provide safe and readily available means