1077-97-0

Usage

Uses

Used in Pharmaceutical Industry:
5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID is used as a key intermediate for the synthesis of various pharmaceuticals due to its potent biological activities. Its carboxylic acid group allows for the formation of esters and amides, facilitating the creation of a wide range of bioactive compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID is used as a precursor in the development of agrochemicals, leveraging its biological properties to enhance crop protection and yield.
Used in Organic Synthesis:
5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID is used as a valuable building block in organic synthesis for the preparation of complex organic molecules. Its iodo substituent is particularly useful in cross-coupling reactions, enabling the formation of carbon-carbon and carbon-heteroatom bonds.
Used in Anti-inflammatory Applications:
5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID is studied for its potential as an anti-inflammatory agent, where it may modulate inflammatory pathways and reduce inflammation-related symptoms.
Used in Anticancer Research:
As an anticancer agent, 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID is being investigated for its potential to inhibit cancer cell growth and proliferation, offering a promising avenue for the development of novel cancer therapeutics.

InChI:InChI=1/C8H5IN2O/c9-5-1-2-7-6(3-5)8(4-12)11-10-7/h1-4H,(H,10,11)

Upstream product

• 78155-77-8 5-amino-1H-indazole-3-carboxylic acid 
• 20780-76-1 5-iodoisatin 
• 1079-47-6 methyl 5-iodo-1H-indazole-3-carboxylate 

Downstream Products

• 1079-47-6 methyl 5-iodo-1H-indazole-3-carboxylate 
• 1607462-13-4 C₂₂H₂₀IN₃O₃S 
• 660822-57-1 N-phenyl-5-iodo-1H-indazole-3-carboxamide 

Relevant academic research and scientific papers

N-heterocyclic carbenes of 5-haloindazoles generated by decarboxylation of 5-haloindazolium-3-carboxylates

Syntheses and properties of 5-fluoro-, chloro- bromo-, and iodo-substituted 11,2-dimethylindazohum-3-carboxylates as new representatives of pseudo-cross-conjugated heterocyclic mesomeric betaines are described, and results of an X-ray single crystal analy

INDAZOLECARBOXAMIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MALARIA

The invention relates to methods of treating or preventing malaria which comprises administering to a patient in need thereof, an effective amount of a 1H-indazole-3-carboxamide derivative of general formula (I), in the form of a base or of an addition salt with an acid, or in the form of a hydrate or of a solvate of said base or acid addition salt.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.

Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors

Compound corresponding to general formula (I): [image] in which, R1 represents a hydrogen or halogen atom, an NH2, NHR2, NHCOR2, NO2, CN, CH2NH2 and CH2NHR2; or alternatively R1 represents an optionally substituted phenyl or an optionally substituted heteroaromatic group; Ar represents an optionally substituted phenyl group or an optionally substituted heteroaromatic group; n represents 0, 1, 2 or 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Application in therapy.

1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS MAPKAP KINASE MODULATORS

The invention provides compounds of the formula: (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a MAPKAP kinase: wherein A is a bond or a group CH2; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra -Rbwherein Ra is a bond, 0, CO, X1C(X2), C(X2)Xl, X1C(X2)X1, S, SO, S02, NRc, SO2NRc or NRcS02; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by 0, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; Rc is hydrogen or C1-4hydrocarbyl; and X1 is O, S or NRc and X2 is =O, =S or =NRc.