1077-97-0

Basic information

• Product Name: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-IODO-3-(1H)INDAZOLE CARBOXYLIC ACID;5-Iodoindazole-3-carboxylic acid;1H-Indazole-3-carboxylic acid, 5-iodo-
• CAS NO: 1077-97-0
• Molecular Formula: C₈H₅IN₂O₂
• Molecular Weight: 288.04
• Mol File: 1077-97-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 375℃
• Boiling Point: 512.118 °C at 760 mmHg
• Flash Point: 263.52 °C
• Appearance: /
• Density: 2.221 g/cm³
• Vapor Pressure: 8.66E-08mmHg at 25°C
• Refractive Index: 1.824
• PKA: 2.84±0.30(Predicted)
• CAS DataBase Reference: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID(1077-97-0)
• EPA Substance Registry System: 5-IODO-1H-INDAZOLE-3-CARBOXYLIC ACID(1077-97-0)

Safety Data

• Hazardous Substances Data: 1077-97-0(Hazardous Substances Data)

Usage

General Description

5-Iodo-1H-indazole-3-carboxylic acid is a chemical compound with the molecular formula C9H6IN3O2. It is a derivative of indazole, a heterocyclic aromatic organic compound. This chemical is commonly used in the synthesis of various pharmaceuticals and agrochemicals due to its potent biological activities. It has been studied for its potential as an anti-inflammatory and anticancer agent. The presence of the carboxylic acid group makes it a useful building block for the preparation of a variety of target molecules and pharmaceutical intermediates. Additionally, its iodo substituent makes it a valuable tool in organic synthesis, particularly in the preparation of complex organic molecules.

InChI:InChI=1/C8H5IN2O/c9-5-1-2-7-6(3-5)8(4-12)11-10-7/h1-4H,(H,10,11)

Upstream product

• 78155-77-8 5-amino-1H-indazole-3-carboxylic acid 
• 1079-47-6 methyl 5-iodo-1H-indazole-3-carboxylate 
• 20780-76-1 5-iodoisatin 

Downstream Products

• 1079-47-6 methyl 5-iodo-1H-indazole-3-carboxylate 
• 1607462-13-4 C₂₂H₂₀IN₃O₃S 
• 660822-57-1 N-phenyl-5-iodo-1H-indazole-3-carboxamide 

Relevant articles and documents

N-heterocyclic carbenes of 5-haloindazoles generated by decarboxylation of 5-haloindazolium-3-carboxylates

Syntheses and properties of 5-fluoro-, chloro- bromo-, and iodo-substituted 11,2-dimethylindazohum-3-carboxylates as new representatives of pseudo-cross-conjugated heterocyclic mesomeric betaines are described, and results of an X-ray single crystal analy

Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors

Compound corresponding to general formula (I): [image] in which, R1 represents a hydrogen or halogen atom, an NH2, NHR2, NHCOR2, NO2, CN, CH2NH2 and CH2NHR2; or alternatively R1 represents an optionally substituted phenyl or an optionally substituted heteroaromatic group; Ar represents an optionally substituted phenyl group or an optionally substituted heteroaromatic group; n represents 0, 1, 2 or 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Application in therapy.

1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS MAPKAP KINASE MODULATORS

The invention provides compounds of the formula: (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a MAPKAP kinase: wherein A is a bond or a group CH2; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra -Rbwherein Ra is a bond, 0, CO, X1C(X2), C(X2)Xl, X1C(X2)X1, S, SO, S02, NRc, SO2NRc or NRcS02; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by 0, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; Rc is hydrogen or C1-4hydrocarbyl; and X1 is O, S or NRc and X2 is =O, =S or =NRc.