107703-78-6

Basic information

• Product Name: ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL
• Synonyms: α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
• CAS NO: 107703-78-6
• Molecular Formula: C₂₀H₂₅NO
• Molecular Weight: 376.19
• Product Categories: Serotonin receptor
• Mol File: 107703-78-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 125-128 °C
• Boiling Point: 434.2 °C at 760 mmHg
• Flash Point: 205.6 °C
• Appearance: white to tan/
• Density: 1.084 g/cm³
• Storage Temp.: Store at RT
• Solubility: DMSO: ≥8mg/mL
• PKA: 14.13±0.20(Predicted)
• CAS DataBase Reference: ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL(107703-78-6)
• EPA Substance Registry System: ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL(107703-78-6)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 107703-78-6(Hazardous Substances Data)

Usage

Uses

MDL 11,939 is a potent and selective SR-2 antagonist. It can also be used to treat psychological and brain disorders.

Biological Activity

Potent, selective and orally active 5-HT 2 receptor antagonist (K i values are 0.54 and 81.6 nM at 5-HT 2A and 5-HT 2C receptors respectively).

InChI:InChI=1/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2

Upstream product

• 38081-60-6 phenyl-piperidin-4-yl-methanol 
• 4455-09-8 2-phenylethyl tosylate 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 133906-84-0 Acetic acid (R)-(1-phenethyl-piperidin-4-yl)-phenyl-methyl ester 
• 132553-87-8 (R)-(1-Phenethyl-piperidin-4-yl)-phenyl-methanol 
• 132553-88-9 (S)-(1-Phenethyl-piperidin-4-yl)-phenyl-methanol 
• 133844-27-6 Acetic acid (1-phenethyl-piperidin-4-yl)-phenyl-methyl ester 

Relevant articles and documents

An efficient synthesis of N-alkyl-4-substituted 3H-pyridine-2,6-dione. Synthesis of isoguvacine and MDL-11,939

An efficient route towards the synthesis of N-alkyl-4-substituted 3H-pyridine-2,6-dione using various N-alkyl-α-sulfonylacetamides and two α,β-unsaturated esters as starting materials is described. Isoguvacine and MDL-11,939 with have potential biological activities were synthesized via this strategy.

N-ARALKYL PIPERIDINE METHANOL DERIVATIVES AND THE USES THEREOF

This invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding