107733-80-2Relevant academic research and scientific papers
STUDIES ON THE SYNTHESIS OF HETEROCYCLIC COMPOUNDS. PART XI. A NOVEL ACCESS TO SOME 2-SUBSTITUTED 4(3H)-QUINAZOLINONES.
Bajardi, Maria Luisa,Daidone, Giuseppe,Raffa, Demetrio,Plescia, Salvatore
, p. 1367 - 1372 (2007/10/02)
Hydrogenolysis of N-(3-R-4-R'-isoxazol-5-yl)-2-nitrobenzamides 1a,b,c with iron powder in acetic acid afforded directly the 2-substituted 4(3H)-quinazolinones 5a,b,c.Additionally, the structure of the methylation product of 2-acetonyl-4(3H)-quinazolinone is elucidated.An attempt devoted to achieve an alternative synthesis of compound 6a by reaction of anthranilamide with ethyl acetoacetate failed to give the desired benzodiazocine but only 2-methyl-4(3H)-quinazolinone 7a was obtained.Products 5a and 9 were evaluated for their antimicrobial activity.
