107747-84-2Relevant articles and documents
Two Biosynthetic Pathways in Jahnella thaxteri for Thaxteramides, Distinct Types of Lipopeptides
Oueis, Emilia,Klefisch, Thorsten,Zaburannyi, Nestor,Garcia, Ronald,Plaza, Alberto,Müller, Rolf
, p. 5407 - 5412 (2019)
The structures of five linear lipopeptides, thaxteramides A1, A2, B1, B2, and C isolated from the myxobacterium Jahnella thaxteri, were elucidated. They have a C-terminal common tetrapeptidic Tyr-Gly-β-Ala-Tyr core but differ in the stereochemistry of the
Oligomers of N-Substituted β2-Homoalanines: Peptoids with Backbone Chirality
Lee, Kang Ju,Lee, Woo Sirl,Yun, Hyosuk,Hyun, Yu-Jung,Seo, Chang Deok,Lee, Chul Won,Lim, Hyun-Suk
, p. 3678 - 3681 (2016)
A new class of peptoid-based peptidomimetics composed of oligomers of N-substituted β2-homoalanines is reported. Design, solid-phase synthesis, and preliminary circular dichroism studies of oligomers of N-alkylated β2-homoalanines co
Synthesis of sterically hindered amine containing azide via chemoselective hydride reduction
Kim, Hwa-Ok
, p. 1713 - 1720 (1998)
The chemoselective reduction of an ester in the presence of an azido group by LiCl/NaBH4 is described. A sterically hindered secondary amine containing an azido group is synthesized by this method.
Structural modification of the P2′ position of 2,7-dialkyl- substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: The discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets
Maibaum, Jürgen,Stutz, Stefan,G?schke, Richard,Rigollier, Pascal,Yamaguchi, Yasuchika,Cumin, Frédéric,Rahuel, Joseph,Baum, Hans-Peter,Cohen, Nissim-Claude,Schnell, Christian R.,Fuhrer, Walter,Gruetter, Markus G.,Schilling, Walter,Wood, Jeanette M.
, p. 4832 - 4844 (2008/03/12)
Due to its function in the rate limiting initial step of the renin-angiotensin system, renin is a particularly promising target for drugs designed to control hypertension, a growing risk to health worldwide. Despite vast efforts over more than two decades
DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT
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Page/Page column 28-29, (2010/11/24)
The present invention relates to novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.