107775-25-7

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 95-48-7 ortho-cresol 
• 84910-98-5 4-methoxy-3-methylbenzene-1-sulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 578-58-5 2-methylmethoxybenzene 
• 108124-10-3 2-methoxy-5-(toluene-4-sulfonyl)-toluene 
• 599-75-7 2-methylphenyl tosylate 

Relevant academic research and scientific papers

Graphite/methanesulfonic acid (GMA) as a new reagent for sulfonylation of phenols and thia-Fries rearrangement of aryl sulfonates to sulfonylphenols

A new facile method for direct sulfonylation of phenols was developed. Graphite in methanesulfonic acid (GMA) was used to prepare sulfonylphenols by sulfonylation of phenol and naphthalene derivatives with p-toluenesulfonic acid (=4-methylbenzenesulfonic acid) (Table 1) and the thia-Fries rearrangement of aryl sulfonates (Table 4). Mechanistic studies showed that the sulfonylation reaction of phenols in GMA occurred through an initial sulfonate formation followed by a thia-Fries rearrangement of the aryl sulfonate by an intermolecular mechanism (Scheme 3).

Al2O3/MeSO3H (AMA) as a new reagent for the thia-Fries rearrangement of arylsulfonates to hydroxyaryl sulfones

A new facile method for thia-Fries rearrangement of arylsulfonates has been developed. A variety of arylsulfonates rearrange in excellent yields in the presence of Al2O3/MeSO3H as a new reagent without the use of any solve