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1078-00-8

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1078-00-8 Usage

General Description

5-Aminotryptamine, also known as 5-HT or serotonin, is a neurotransmitter and a derivative of the amino acid tryptophan. It is an important chemical in the regulation of mood, appetite, and sleep. 5-AMINOTRYPTAMINE is also involved in the control of anxiety, aggression, and body temperature, and plays a role in the perception of pain. It is found in the central nervous system and the gastrointestinal tract, and is believed to be involved in a wide range of physiological functions. Imbalances in 5-AMINOTRYPTAMINE levels have been associated with various psychological and neurological disorders, such as depression, anxiety, and migraine. It is also the target of many pharmaceutical drugs used to treat these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1078-00-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,7 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1078-00:
(6*1)+(5*0)+(4*7)+(3*8)+(2*0)+(1*0)=58
58 % 10 = 8
So 1078-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H13N3/c11-4-3-7-6-13-10-2-1-8(12)5-9(7)10/h1-2,5-6,13H,3-4,11-12H2

1078-00-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(2-aminoethyl)-1H-indol-5-amine

1.2 Other means of identification

Product number -
Other names 5-Aminotryptamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1078-00-8 SDS

1078-00-8Downstream Products

1078-00-8Relevant articles and documents

Structural understanding of 5-(4-hydroxy-phenyl)-N-(2-(5-methoxy-1H-indol-3-yl)-ethyl)-3-oxopentanamide as a neuroprotectant for Alzheimer's disease

Green, Jakob,Jiang, Yuqi,Kellogg, Glen E.,Saathoff, John,Xu, Yiming,Zhang, Shijun

, (2021)

In our continuing efforts to develop novel neuroprotectants for Alzheimer's disease (AD), a series of analogs based on a lead compound that was recently shown to target the mitochondrial complex I were designed, synthesized and biologically characterized to understand the structure features that are important for neuroprotective activities. The results from a cellular AD model highlighted the important roles of the 4-OH on the phenyl ring and the 5-OCH3 on the indole ring of the lead compound. The results also demonstrated that the β-keto moiety can be modified to retain or improve the neuroprotective activity. Docking studies of selected analogs to the FMN site of mitochondrial complex I also supported the observed neuroprotective activities. Collectively, the results provide further information to guide optimization and development of analogs based on this chemical scaffold as neuroprotectants with a novel mechanism of action for AD.

SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN

-

Page/Page column 54, (2011/05/05)

Disclosed herein are small molecule heterocyclic inhibitors of sepiapterin reductase (SPR), and pro-drugs and pharmaceutically acceptable salts thereof. The Also featured are pharmaceutical compositions of the compounds and uses of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, and neuropathic pain)

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