1078130-52-5

Basic information

• Product Name: 8-Fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester
• Synonyms: 8-Fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester;METHYL 8-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-2-CARBOXYLATE
• CAS NO: 1078130-52-5
• Molecular Formula: C₁₁H₈FNO₃
• Molecular Weight: 221.1845232
• EINECS: -0
• Mol File: 1078130-52-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 328.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.366±0.06 g/cm3(Predicted)
• PKA: -1.02±0.70(Predicted)
• CAS DataBase Reference: 8-Fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester(1078130-52-5)
• EPA Substance Registry System: 8-Fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester(1078130-52-5)

Safety Data

• Hazardous Substances Data: 1078130-52-5(Hazardous Substances Data)

Usage

General Description

8-Fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid methyl ester is a synthetic organic compound with the molecular formula C12H9FN2O3. It is a methyl ester derivative of 8-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid, which belongs to the quinolone class of antibiotics. 8-Fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester has potential antimicrobial and antibacterial properties and may be used in pharmaceutical research and drug development. Its chemical structure and properties make it an important target for medicinal chemistry studies aimed at developing new antibiotics and antimicrobial agents.

Upstream product

• 110163-28-5 methyl 2-[(2-fluorophenyl)amino]but-2-enedioate 
• 1314141-66-6 dimethyl (2E)-2-[(2-fluorophenyl)amino]but-2-enedioate 
• 348-54-9 2-Fluoroaniline 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 1432730-60-3 8-fluoro-4-(4-fluorophenyl)quinoline-2-carboxamide 
• 1432731-49-1 8-fluoro-4-(4-fluorophenyl)quinoline-2-carboxylic acid 

Relevant articles and documents

Acylhydrazone Switches: E/Z Stability Reversed by Introduction of Hydrogen Bonds

We report a series of acylhydrazone-based switches, of which double bond rotation can be stimulated by a pH response. The switches prefer Z rather than E configuration in the ground state because of the intramolecular hydrogen bonding, which was analyzed both thermodynamically and kinetically. Solvation studies show a linear relationship between the isomerization energy in Z/E states (ΔGE/Zo) of the switches and the hydrogen bond basicity scales (β and DN) of the solvent. This solvent effect was also found to be relative to the skeleton of compound, the less shield of hydrogen bond domain the more sensitivity to the solvent environment. By introducing multiple intramolecular hydrogen bonds, the Z isomer completely predominates for compound 4, offering an advantage over a full E/Z isomerization switching.

QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.