1078160-07-2Relevant academic research and scientific papers
Syntheses of potassium 1,1-dioxopyrido[4,3-e]-1,4,2-dithiazine-3-thiolate and its application to the synthesis of novel sulfonamides with potential biological activity
Brzozowski, Zdzislaw,Saczewski, Franciszek,Slawinski, Jaroslaw
, p. 1407 - 1413 (2008)
(Chemical Equation Presented) Potassium 1,1-dioxopyrido[4,3-e]-1,4,2- dithiazine-3-thiolate 2 has been synthesized and applied to the syntheses of 7H-1,1-dioxopyrido[4,3-e]-1,4,2-dithiazolium-3-thiolate 3 and 3-methylthiopyrido[4,3-e]-1,4,2-dithiazine 1,1-dioxide 4 which provided easy access to a variety of its 3-amino derivatives 5-10. Hydrazinolysis of 7, 8 and 10 afforded the corresponding 3-amino-2-(1,4-dihydro-4-thioxopyrid-3-ylsulfonyl) guanidines 11-13. Subsequent reaction of 12 with 4-chlorobenzaldehyde gave condensation product 14. 1,4-Dihydro-2-thioxopyridine-3-sulfonamide 15 was also prepared from the potassium salt 2 upon alkaline hydrolysis, whereas alkylation of 15 gave the appropriate S-substituted derivatives 16-19 or S,N-disubstituted compounds 20-21.
