1078587-16-2Relevant academic research and scientific papers
High yield synthesis of 4H-1,4-benzothiazine-1,1-dioxide derivatives
De Montis, Stefania,Fattuoni, Claudia,Cadoni, Enzo,Cabiddu, Maria G.,Usai, Michele,Cabiddu, Salvatore
experimental part, p. 1445 - 1449 (2009/04/07)
(Chemical Equation Presented) 4H-1,4-Benzothiazine-1,1-dioxide derivatives were synthesized through a sequence of almost quantitative reactions. The commercial starting material 2-(methylsulfanyl)aniline was Boc-protected, N-acylated and oxidized at the sulfur atom to obtain a sulfonyl derivative. An anionic transposition of the acyl group followed by a simultaneous deprotection-cyclization gave the title products in excellent yields. All products and intermediates were fully characterized.
