1078627-32-3

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 924307-76-6 (S)-2-amino-8-nonenoic acid 
• 1078627-30-1 (S)-2-amino-non-8-enoic acid hydrochloride 

Downstream Products

• 1078627-36-7 (3R,5S)-5-((1R,2S)-1-cyclopropanesulfonylcarbamoyl-2-vinyl-cyclopropylcarbamoyl)-1-[(S)-2-(4-fluoro-phenylamino)-non-8-enoyl]-pyrrolidin-3-yl 4-fluoro-isoindoline-2-carboxylate 
• 1078623-96-7 (2R,6S,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-5,16-dioxo-6-((4-fluoro-phenyl)-amino)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate 
• 1315325-71-3 (2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide 
• 1315326-97-6 (2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-1-((S)-2-(4-fluorophenylamino)non-8-enoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide 

Relevant academic research and scientific papers

HCV PROTEASE INHIBITORS

This invention relates to compounds of Formula (I), (II), or (III) shown in the specification. These compounds can be used to treat hepatitis C virus infection.

NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.