1078723-22-4Relevant academic research and scientific papers
First total synthesis of the phenolic 7,8-dihydro-8-oxoprotoberberine alkaloid, cerasonine
Le, Thanh Nguyen,Cho, Won-Jea
experimental part, p. 1026 - 1029 (2009/07/18)
First total synthesis of the phenolic protoberberine, cerasonine, was accomplished through a coupling reaction between o-toluamide and benzonitrile. This key step provided the 3-arylisoquinoline which was then successfully converted to 7,8-dihydro-8-oxoprotoberberine through an intramolecular S N2 reaction.
