1078734-22-1Relevant academic research and scientific papers
Rh(III)-catalyzed decarboxylative ortho -heteroarylation of aromatic carboxylic acids by using the carboxylic acid as a traceless directing group
Qin, Xurong,Sun, Denan,You, Qiulin,Cheng, Yangyang,Lan, Jingbo,You, Jingsong
supporting information, p. 1762 - 1765 (2015/04/14)
Highly selective decarboxylative ortho-heteroarylation of aromatic carboxylic acids with various heteroarenes has been developed through Rh(III)-catalyzed two-fold C-H activation, which exhibits a wide substrate scope of both aromatic carboxylic acids and heteroarenes. The use of naturally occurring carboxylic acid as the directing group avoids troublesome extra steps for installation and removal of an external directing group.
17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES
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Page/Page column 28, (2011/04/14)
The invention relates to 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) inhibitors, the preparation thereof and the use thereof for the treatment and prophylaxis of hormone-related, especially estrogen-related or androgen-related, diseases.
Iron-catalyzed oxidative coupling of arylboronic acids with benzene derivatives through homolytic aromatic substitution
Uchiyama, Nanase,Shirakawa, Eiji,Nishikawa, Ryo,Hayashi, Tamio
supporting information; experimental part, p. 11671 - 11673 (2011/12/05)
Fe(OTf)3-1,10-phenanthroline catalyzes oxidative coupling of arylboronic acids with benzene derivatives using t-BuOOt-Bu as an oxidant. The reaction proceeds through homolytic aromatic substitution with aryl radicals generated from arylboronic acids and t-BuO.
Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1)
Bey, Emmanuel,Marchais-Oberwinkler, Sandrine,Werth, Ruth,Negri, Matthias,Al-Soud, Yaseen A.,Kruchten, Patricia,Oster, Alexander,Frotscher, Martin,Birk, Barbara,Hartmann, Rolf W.
experimental part, p. 6725 - 6739 (2009/11/30)
17β-Estradiol (E2), the most potent female sex hormone, stimulates the growth of mammary tumors and endometriosis via activation of the estrogen receptor α (ERα). 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1), which is responsible for the catalytic r
