1078738-13-2Relevant academic research and scientific papers
Stereocontrolled total synthesis of amphidinolide X via a silicon-tethered metathesis reaction
Rodriguez-Escrich, Carles,Urpi, Felix,Vilarrasa, Jaume
supporting information; experimental part, p. 5191 - 5194 (2009/06/06)
(Chemical Equation Presented) Two esterifications and an RCM to create the challenging trisubstituted C12-C13 double bond were required in the total synthesis of amphidinolide X (1) reported here. Assembling the three fragments in this order, no RCM occurred or the process yielded mainly isomer Z However, generating the E double bond first, by a new variant of a Si-tethered metathesis (using Schrock's catalyst), and carrying out the esterification and macrolactonization steps later, 1 was obtained exclusively.
