1079038-88-2

Basic information

• Product Name: C₁₆H₇F₄N₃O₂
• CAS NO: 1079038-88-2
• Molecular Weight: 349.244
• Mol File: 1079038-88-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₆H₇F₄N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₇F₄N₃O₂(1079038-88-2)
• EPA Substance Registry System: C₁₆H₇F₄N₃O₂(1079038-88-2)

Safety Data

• Hazardous Substances Data: 1079038-88-2(Hazardous Substances Data)

Upstream product

• 4640-67-9 3-(4-fluorophenyl)-3-oxopropionitrile 
• 41153-85-9 5-trifluoromethylbenzofuroxan 

Relevant articles and documents

Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2- carbonitrile di-N-oxides

In a continuing effort to identify new active compounds for combating Chagas disease and other neglected diseases, our research group synthesized and evaluated 23 3-arylquinoxaline-2-carbonitrile di-N-oxides against Trypanosoma cruzi. Five of them presented IC50 values of the same magnitude as the standard drug Nifurtimox, making them valid as new lead compounds. The optimized molecular structures of 23 derivatives represented by 1497 types of DRAGON descriptors were subjected to linear regression analysis, and the derived QSAR was shown to be predictive. In this way, we achieved a rational guide for the proposal of new candidate structures whose activities still remain unknown.

Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents

As a continuation of our research and with the aim of obtaining new antimalarial agents, new series of 3-phenylquinoxaline 1,4-di-N-oxide derivatives have been synthesized following the classical Beirut reaction. Antiplasmodial activity was evaluated in v