1079038-89-3Relevant academic research and scientific papers
Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2- carbonitrile di-N-oxides
Vicente, Esther,Duchowicz, Pablo R.,Benitez, Diego,Castro, Eduardo A.,Cerecetto, Hugo,Gonzalez, Mercedes,Monge, Antonio
scheme or table, p. 4831 - 4835 (2010/10/21)
In a continuing effort to identify new active compounds for combating Chagas disease and other neglected diseases, our research group synthesized and evaluated 23 3-arylquinoxaline-2-carbonitrile di-N-oxides against Trypanosoma cruzi. Five of them presented IC50 values of the same magnitude as the standard drug Nifurtimox, making them valid as new lead compounds. The optimized molecular structures of 23 derivatives represented by 1497 types of DRAGON descriptors were subjected to linear regression analysis, and the derived QSAR was shown to be predictive. In this way, we achieved a rational guide for the proposal of new candidate structures whose activities still remain unknown.
Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents
Vicente, Esther,Lima, Lidia M.,Bongard, Emily,Charnaud, Sarah,Villar, Raquel,Solano, Beatriz,Burguete, Asuncion,Perez-Silanes, Silvia,Aldana, Ignacio,Vivas, Livia,Monge, Antonio
, p. 1903 - 1910 (2008/12/22)
As a continuation of our research and with the aim of obtaining new antimalarial agents, new series of 3-phenylquinoxaline 1,4-di-N-oxide derivatives have been synthesized following the classical Beirut reaction. Antiplasmodial activity was evaluated in v
