1079039-82-9Relevant academic research and scientific papers
Salicylanilides: Selective inhibitors of interleukin-12p40 production
Brown, Michael E.,Fitzner, Jeffrey N.,Stevens, Tracey,Chin, Wilson,Wright, Clifford D.,Boyce, Jim P.
experimental part, p. 8760 - 8764 (2009/04/05)
Interleukin (IL)-12p40, a subunit component of both IL-12 and IL-23, is being widely studied for its role in inflammatory disease. As part of an effort to profile cellular signaling pathways across different cell types, we report salicylanilide inhibitors of IL-12p40 production in stimulated dendritic cells. Based on a hypothesis that a desirable therapeutic profile is one that could block IL-12p40 but not IL-6 production, we engaged in directed analoging. This resulted in salicylanilides with similar IL-12p40 related potency but enhanced selectivity relative to IL-6 production.
