1079178-13-4

Usage

Uses

Used in Pharmaceutical Industry:
5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-amine is used as a key intermediate in the synthesis of aryl urea derivatives. These derivatives are known for their potential as gamma secretase modulators, which play a crucial role in the treatment of beta-amyloid related diseases such as Alzheimer's Disease. By modulating the activity of gamma secretase, these aryl urea derivatives can help regulate the production and accumulation of beta-amyloid plaques in the brain, offering a promising therapeutic approach for Alzheimer's patients.

Upstream product

• 75711-00-1 2-chloro-3-methoxy-5-nitropyridine 
• 1079178-12-3 3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-nitropyridine 

Downstream Products

• 1255700-82-3 (R)-2-(8-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-ylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)ethanol 
• 1240608-97-2 [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine 

Relevant academic research and scientific papers

FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF

The present disclosure relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.

FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF

The present invention relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.

FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF

The present disclosure relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

The design and the synthesis of several chemical subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of pyridone 4 into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo p

NEW COMPOUNDS MODULATING GAMMA-SECRETASE AND THEIR USE IN THE TREATMENT OF ALPHA BETA RELATED PATHOLOGIES, SUCH AS ALZHEIMER'S DISEASE

The present invention relates to novel compounds of formulae (I) and (II) and therapeutically acceptable salts thereof, their pharmaceutical compositions processes for making them and their use in therapeutic methods for treatment and/or prevention of var